Publications | Roskin Lab (2024)

Pham, TD; Chng, MH Y; Roskin, KM; Jackson, KJ L; Nguyen, KD; Glanville, J; Lee, J; Engleman, EG; Boyd, SD.High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance. Mucosal Immunology.2017;10:1468-1479.

Ellebedy, AH; Jackson, KJ L; Kissick, HT; Nakaya, HI; Davis, CW; Roskin, KM; McElroy, AK; Oshansky, CM; Elbein, R; Thomas, S; et al.Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. Nature Immunology.2016;17:1226-1234.

Hoh, RA; Joshi, SA; Liu, Y; Wang, C; Roskin, KM; Lee, J; Pham, T; Looney, TJ; Jackson, KJ L; Dixit, VP; et al.Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. Journal of Allergy and Clinical Immunology.2016;137:157-167.

Collins, AM; Wang, Y; Roskin, KM; Marquis, CP; Jackson, KJ L.The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains. Philosophical Transactions of the Royal Society of London: Biological Sciences.2015;370:20140236.

Roskin, KM; Simchoni, N; Liu, Y; Lee, J; Seo, K; Hoh, RA; Pham, T; Park, JH; Furman, D; Dekker, CL; et al.IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Science Translational Medicine.2015;7:302ra135.

Wang, C; Liu, Y; Cavanagh, MM; Le Saux, S; Qi, Q; Roskin, KM; Looney, TJ; Lee, J; Dixit, V; Dekker, CL; et al.B-cell repertoire responses to varicella-zoster vaccination in human identical twins. Proceedings of the National Academy of Sciences of USA.2015;112:500-505.

Jackson, KJ L; Liu, Y; Roskin, KM; Glanville, J; Hoh, RA; Seo, K; Marshall, EL; Gurley, TC; Moody, MA; Haynes, BF; et al.Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host and Microbe.2014;16:105-114.

Wang, C; Liu, Y; Xu, LT; Jackson, KJ L; Roskin, KM; Pham, TD; Laserson, J; Marshall, EL; Seo, K; Lee, J; et al.Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. Journal of immunology (Baltimore, Md. : 1950).2014;192:603-611.

Parameswaran, P; Liu, Y; Roskin, KM; Jackson, KK L; Dixit, VP; Lee, J; Artiles, KL; Zompi, S; Jose Vargas, M; Simen, BB; et al.Convergent antibody signatures in human dengue. Cell Host and Microbe.2013;13:691-700.

Liao, H; Lynch, R; Zhou, T; Gao, F; Alam, SM; Boyd, SD; Fire, AZ; Roskin, KM; Schramm, CA; Zhang, Z; et al.Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature.2013;496:469-476.

Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O’Brien, E; VanCauwenbergh, B; Perentesis, J; et al.HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific Reports.2023;13:12433.

Dexheimer, PJ; Pujato, M; Roskin, KM; Weirauch, MT.VExD: a curated resource for human gene expression alterations following viral infection. Editor, McIntyre L.G3-Genes Genomes Genetics.2023;13:jkad176.

Shi, T; Burg, AR; Caldwell, JT; Roskin, KM; Castro-Rojas, CM; Chukwuma, PC; Gray, GI; Foote, SG; Alonso, JA; Cuda, CM; et al.Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality. The Journal of Clinical Investigation.2023;133:e170191.

Rossi, AP; Tremblay, S; Castro-Rojas, CM; Burg, AA; Roskin, KM; Gehman, JM; Rike-Shields, A; Alloway, RR; Brailey, P; Allman, D; et al.Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates. American Journal of Transplantation.2023;23:759-775.

Gill, K; Moore, C; Nwogu, O; Kroner, JW; Chang, W; Stevens, ML; Kyzy, AB; Biagini, JM; Devonshire, AL; Kottyan, L; et al.B cell repertoire in children with skin barrier dysfunction supports altered IgE maturation associated with allergic food sensitization. 2023;4:2023.02.01.526538.

Garrett, MC; Albano, R; Carnwath, T; Shah, S; Woo, D; Lamba, M; Plas, DR; Paranjpe, A; Roskin, K; Zhao, C; et al.Chromatin structure predicts survival in glioma patients. Scientific Reports.2022;12:8221.

Williams, JG; Joshi, R; Haslam, D; Yehya, N; Jones, RL; Paranjpe, A; Pujato, M; Roskin, KM; Lahni, PM; Wong, HR; et al.Multi-omic characterization of pediatric ARDS via nasal brushings. Respiratory Research.2022;23:181.

McDaniel, MM; Chawla, AS; Jain, A; Meibers, HE; Saha, I; Gao, Y; Jain, V; Roskin, K; Way, SS; Pasare, C.Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. Science Immunology.2022;7:eabk0182.

Shi, T; Roskin, K; Baker, BM; Woodle, ES; Hildeman, D.Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution. Frontiers in Immunology.2021;12:750754.

Chen, JA; Hou, Y; Roskin, KM; Arber, DA; Bangs, CD; Baughn, LB; Cherry, AM; Ewalt, MD; Fire, AZ; Fresard, L; et al.Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance. Blood Advances.2021;5:3492-3496.

Yang, F; Nielsen, SC A; Hoh, RA; Röltgen, K; Wirz, OF; Haraguchi, E; Jean, GH; Lee, JY; Pham, TD; Jackson, KJ L; et al.Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Science.2021;372:738-741.

Wagar, LE; Salahudeen, A; Constantz, CM; Wendel, BS; Lyons, MM; Mallajosyula, V; Jatt, LP; Adamska, JZ; Blum, LK; Gupta, N; et al.Modeling human adaptive immune responses with tonsil organoids. Nature Medicine.2021;27:125-135.

Rai, MA; Hammonds, J; Pujato, M; Mayhew, C; Roskin, K; Spearman, P.Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Retrovirology.2020;17:35.

Woodle, ES; Tremblay, S; Rossi, A; Rojas, CC; Alloway, R; Roskin, K; Allman, D; Hildeman, D.Plasma cell targeting to prevent antibody-mediated rejection. American Journal of Transplantation.2020;20 Suppl 4:33-41.

Moore, C; Gao, B; Roskin, KM; Vasilescu, EM; Addonizio, L; Givertz, MM; Madsen, JC; Zorn, E.B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy. American Journal of Transplantation.2020;20:1431-1438.

Roskin, K; Spearman, P.HIV-1 Broadly Neutralizing Antibodies Take the Road Less Traveled, and That Makes All the Difference. Cell Host and Microbe.2020;27:487-488.

Hoh, RA; Joshi, SA; Lee, J; Martin, BA; Varma, S; Kwok, S; Nielsen, SC A; Nejad, P; Haraguchi, E; Dixit, PS; et al.Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy. Science Immunology.2020;5:eaay4209.

Roskin, KM; Jackson, KJ L; Lee, J; Hoh, RA; Joshi, SA; Hwang, K; Bonsignori, M; Pedroza-Pacheco, I; Liao, H; Moody, MA; et al.Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth. Nature Immunology.2020;21:199-209.

Nielsen, SC A; Roskin, KM; Jackson, KJ L; Joshi, SA; Nejad, P; Lee, J; Wagar, LE; Pham, TD; Hoh, RA; Nguyen, KD; et al.Shaping of infant B cell receptor repertoires by environmental factors and infectious disease. Science Translational Medicine.2019;11:eaat2004.